Is ASP.NET Ajax compatible with ClientScriptManager CallBack functions?

The current project usesClientScriptManager CallBack functions to implement a simple callback scenario. Is it OK to add ASP.NET Ajax and use the both ASP.NET Ajax and ClientScriptManager CallBack on the same page?In Ajax,we will use ScriptManager.RegisterClientScriptResource?to register client script.Try to take a look at this link for details -http://ajax.asp.net/docs/mref/M_System_Web_UI_ScriptManager_RegisterClientScriptResource_3_2a609ef4.aspx